Treatment Procedures for Hemophilia
In people who are diagnosed with hemophilia, blood does not clot normally. It implies that the body is unable to stop bleeding, both on the inside and outside. Treatment options to cure hemophilia depend on its severity. There are several treatment options available. Here, we will discuss the some of the common, popular ones:
Replacement therapy
The primary treatment for hemophilia in severe cases involve the replacement of a particular clotting factor. It may be injected in the body via a tube that is inserted in the vein. Replacement therapy helps curtail the ongoing bleeding episode. However, if needed, it might also be administered regularly in extreme hemophilia cases. Some people continually take replacement therapy. The healthy clotting factor might be availed from donated blood. Recombinant clotting factors, which are lab-made, might also be used.
Medications
- Desmopressin
Desmopressin is used in mild cases of hemophilia. It is a human-made hormone. It can help treat severe cases of hemophilia A and hemophilia B. The hormone encourages the body to increase the von Willebrand factor and factor VIII. The former binds and carries factor VIII, which stays longer in the bloodstream. It is usually taken as a nasal spray or gradually injected into the vein. - Antifibrinolytics
These are the clot-preserving medications that help in preventing the breakdown of clots. They include both epsilon-aminocaproic acid and tranexamic acid. These medications can be used in addition to replacement therapy. Such medicines are given in the form of a pill to prevent the blood clots from breaking down. They might also be used to cure the ongoing bleeding of the nose or mouth, or mild intestinal bleeding. - Fibrin sealants
Such medicines are applied to the wound directly. They help in healing and promote clotting. These work well in dental procedures too. - Emicizumab
It helps replace the function of the clotting factor VIII, instead of directly replacing the missing protein. Marketed as Hemlibra, it is a popular treatment option for hemophilia, and helps lower or prevent the frequency of bleeding episodes. It can be injected into the skin directly.
- Aminocaproic acid
It is another treatment for hemophilia, which is either taken as a liquid or as a pill. Its brand name is Amicar, and it helps in preventing the breakdown of blood clots. It is used to stop the bleeding in the mouth and gastrointestinal system, or after tooth extraction.
Gene therapy
Today, several researchers are working on a way to rectify the faulty gene that causes hemophilia. However, this form of treatment is not well-developed yet. As a result, it is not a widely accepted form of hemophilia treatment. However, clinical trials of gene therapy are on-going.